Optimizing Diagnosis and Treatment for Patients with Peripheral T-Cell Lymphoma

Presented by the Johns Hopkins School of Medicine and

the Institute for Johns Hopkins Nursing.

Supported by an educational grant from Seattle Genetics, Inc.

Progress in the management of patients with peripheral T-cell lymphomas (PTCLs), a rare and heterogeneous disease, has been hampered by a lack of clinical trials for new and more effective therapies. With the current standard of care in the first‐line setting, control of the disease has been disappointing, with patients still experiencing frequent early relapse, with progression‐free survival (PFS) lasting less than 1 year, and their overall survival (OS) often lasting less than 2 years. However, brentuximab vedotin (BV) is a CD30‐targeted drug‐antibody conjugate that is approved for treating patients with relapsed anaplastic large cell lymphoma. Recently, the indication for BV was expanded to include the front‐line treatment of patients with CD30-positive PTCLs in combination with CHP (cyclophosphamide, doxorubicin, and prednisone). BV plus CHP combination therapy was associated with doubling the median PFS as compared to standard anthracycline-based therapy, which shows promise in the overall management of PTCL patients. This activity will review the pathophysiology and current state of management of patients with PTCL and discusses the role of BV in the future first‐line management.

At the end of this activity, healthcare providers should be able to appraise the utility of recently approved therapies for patients with PTCL and meld knowledge of the pathophysiology of PTCL, current guidelines, and recent clinical findings into care plans that improve patient outcomes.

This activity is intended for hematology/oncology physicians, nurse practitioners/physician assistants, and nurses, as well as other healthcare providers who are involved in the care of patients with PTCLs. No prerequisites required.

After participating in this activity, the participant will demonstrate the ability to:
  •   • IDENTIFY currently available diagnostic tools and employ these tools into the differential diagnosis of PTCL.
  •   • RECOGNIZE the presentation of PTCL and its key physiological and molecular drivers.
  •   •  FORMULATE treatment plans for patients with treatment-naïve PTCL that appropriately incorporate newly FDA-approved agents, based on recent key clinical findings.

The Johns Hopkins School of Medicine and the Institute for Johns Hopkins Nursing take responsibility for the content, quality, and scientific integrity of this CME/CNE activity.

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Johns Hopkins School of Medicine and the Institute for Johns Hopkins Nursing. The Johns Hopkins School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

The Institute for Johns Hopkins Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

Credit Designation Statements – The Johns Hopkins School of Medicine designates this enduring material internet activity for a maximum of 0.5 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This .5 contact hour educational activity is provided by the Institute for Johns Hopkins Nursing. Claim only those contact hours actually spent in the activity. Statements will be awarded for this educational activity until September 8, 2020.

The estimated time to complete this activity: 30 minutes.

Release date: September 9, 2019     Expiration date: September 9, 2020

Policy on Presenter and Provider Disclosure
It is the policy of the Johns Hopkins School of Medicine and the Institute for Johns Hopkins Nursing that the speaker and provider globally disclose conflicts of interest. The Johns Hopkins School of Medicine OCME has established policies that will identify and resolve conflicts of interest prior to this educational activity. Detailed disclosure will be made prior to presentation of the education.

Full Disclosure Policy Affecting CME Activities
As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), Johns Hopkins School of Medicine Office of Continuing Medical Education (OCME) requires attested and signed global disclosure of the existence of all financial interests or relationships with commercial interest from any individual in a position to control the content of a CME activity sponsored by OCME. The following relationships have been reported for this activity:

Planner Disclosures
Dr. Ettinger reports receiving consulting fees from BeyondSpring Pharmaceuticals, Inc, Boehringer Ingelheim Vetmedica, Inc, Bristol-Myers Squibb Company, Celgene Corporation, Eli Lilly and Company, Genentech, Inc, and Guardant Health, Inc, and Sanofi-Aventis.

No other individual with the opportunity to affect this educational content has indicated any financial interests or relationships with a commercial entity.

Note: Grants to investigators at the Johns Hopkins University are negotiated and administered by the institution that receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).

Johns Hopkins School of Medicine Chair and Planner
David S. Ettinger, MD

Alex Grass Professor of Oncology
Sidney Kimmel Comprehensive Cancer
Baltimore, Maryland

Faculty Author
Douglas E. Gladstone, MD
Associate Professor of Oncology
Johns Hopkins School of Medicine
Clinical Director, Hematologic Malignancies and Bone Marrow Transplantation Program
Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland

Peer Reviewer
Susan L. Gearhart, MD

Associate Professor of Surgery
Director of Pharmacy
Johns Hopkins School of Medicine
Baltimore, Maryland

Nurse Planner
Rebecca Barshick, RN, MSN
Nurse Educator
The Institute for Johns Hopkins Nursing
Baltimore, Maryland

Nurse Reviewer
Oncology and Hematology Clinical Nurse Specialist
Ambulatory Oncology
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins Hospital and Greenspring Oncology
Baltimore, Maryland

Non-Endorsement of Products
The Institute for Johns Hopkins Nursing and the American Nurses Credentialing Center do not endorse the use of any commercial products discussed or displayed in conjunction with this educational activity.

OFF-LABEL PRODUCT DISCUSSION – No faculty member has indicated that their presentation will include information on off-label products.

DISCLAIMER – The opinions and recommendations expressed by faculty and other experts whose input is included in this activity are their own. This activity is produced for educational purposes only. Use of Johns Hopkins School of Medicine name implies review of educational format, design, and approach. Please review the complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings, and adverse effects before administering pharmacologic therapy to patients.

I certify that I am participating in this Johns Hopkins School of Medicine activity for CME-accredited training and/or educational purposes.

I understand that while I am participating in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the “Privacy Regulations”). Protected health information is information about a person's health or treatment that identifies the person.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos, on any social media site (eg, Facebook, Twitter, etc.), in any electronic messaging program or through any portable electronic device.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is: Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail: HIPAA@jhmi.edu.

"The Office of Continuing Medical Education at the Johns Hopkins School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certify that the visitor is here for training, education and/or observation purposes only."

For CME questions, please contact the CME Office at 410-955-2959 or e-mail cmenet@jhmi.edu.
Johns Hopkins School of Medicine
Office of Continuing Medical Education
720 Rutland Avenue/ Turner 20
Baltimore, Maryland 21205-2195
Reviewed & Approved by: General Counsel, Johns Hopkins Medicine (4/1/03) (Updated 4/09 and 3/14)

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The following is an interactive case module designed to help you gauge your basic knowledge of the topic and then direct you to areas you may need to focus on. It consists of 3 sections: an unaccredited preassessment, an interactive case study, and a CE postassessment and evaluation. All 3 sections must be completed to receive CE credit. A certificate of participation will be available online immediately following successful completion of the activity.


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Postassessment and Evaluation

This activity was developed in collaboration with ASiM.

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